Drug resistance in oncology

摘要: Part 1 Physiological resistance in solid tumours: angiogenesis and blood flow tumours, Mark W. Dewhirst intra- extracellular pH tumours - influence on therapeutic response, Chang Song et al oxygenation of Peter Vaupel physiological to the treatment Rakesh K. Jain role oncogenes tumour-suppressor genes tumour angiogenesis, Lynn C. Yeoman matrix invasion, metastasis Yves A. de Clerck Walter E. Laug prediction response using magnetic resonance spectroscopy, Paul Okunieff. 2 Biological resistance: heterogeneous clonal subpopulations John T. Leith Seth Michelson subpopulation interactions expression drug resistance, Gloria H. Heppner Bonnie Miller leukemia, William R. Waud Daniel P. Griswold, Jr site effects central nervous system Henry S. Friedman Clifford Schold, vivo antitumour alkylating agents, Beverly Teicher characteristics metastatic phenotype, Vincent J. Hearing. 3 Biochemical glutathione associated enzymes cellular radiation, peroxide hydroperoxides, Biaglow Steve Tuttle metallothioneins Nagahiro Saijo Stephen Lazo glutathione-S-transferases, Ciaccio Kenneth D. Tew oxazaphosphorine-specific acquired Norman Sladek tumour-cell metabolism Dennis Chapman Garth Powis P-glycoprotein mediated multi-drug Bernard Futscher Dalton topoisomerase-related mechanisms Fernandes al. 4 The hormones, growth factors oncogenes: acquisition antioestrogen breast cancer, Robert Clarke Marc Lippman chorionic gonadotropin a tumouristatic preventive agent Irma Russo roles TGF-B FGF progression metastastis, Danny Welch Motowo Nakajima possible contribution evolution novo multidrug Kerbel MacDougall signal transduction gene during mammalian cell ionizing Halllahan 5 Clinical aspects cancer chemotherapy clinical evidence for Louis Ayash