Aspects of Metabolic Change After Hyperthermia

摘要: Heat treatment of cells and tissues leads to instantaneous molecular metabolic changes. These rapid changes are already observed at temperature ranges (40-45° C) which used in tumour therapy. Such an immediate response is not seen after exposure doses ionizing radiation within the therapeutic range. Under these conditions usually only several hours or days (Streffer 1969; Altman et al. 1970). On other hand, it very well understood today that DNA damage effects on chromosomal level most important involved mechanism reproductive cell death (Alperl979; Streffer van Beuningen 1985). The heat-induced killing less clear. However, evident processes cytoplasm as distinct from nucleus for mechanisms (Hahn 1982; 1982). Two principal can be during heat treatments 1985): 1. Conformational changes, lead destabilization macromolecules multimolecular structures. 2. Elevated temperatures, induce increased rates reactions. As a consequence turnover metabolites occurs followed by disregulation.