Vascular targeting therapy: potential benefit depends on tumor and host related effects.

摘要: [1]. With an adequate blood supply unrestricted growth of the primary tumor and metastatic spread can occur. The vasculature that develops arises from pre-existing normal host by process angiogenesis [2]. In adults, is normally only associated with certain physiological processes including female reproductive cycle, pregnancy, muscular hypertrophy wound healing [3]. How-ever, it seen a number pathological condi-tions, rheumatoid arthritis, diabetes, macular degeneration, psoriasis, cardiovascular disease course cancer actual triggers initiate are not fully established. Hypoxia clearly one factor plays significant role [4], but other «non-hypoxia factors» have also been implicated loss suppressor gene function oncogene activation [4, 5]. Once triggered, angio-genic starts release angiogenic factors, primarily vascular endothelial (VEGF), cells [6]. These factors then set in motion cascade events include enzymatic destruction basal membrane cells, migration into extracellu-lar matrix to form sprouts, cell division away sprout tip [7]. Solid strands endothe-lial formed extracellular matrix, lumen within those strands, neighbouring sprouts fuse loops, loops new buds emerge Functional vessels finally established (Fig. 1).