Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy.

作者: Rakesh K. Jain

DOI: 10.1038/NM0901-987

关键词:

摘要: … Accumulating data indicate that it can also potentiate the effects of radiation and chemotherapy 6 ; combined therapy can even produce long-term cures in mice 2,3,7 . This …

参考文章(26)
Timothy P. Padera, Dai Fukumura, Ananth Kadambi, Peter Carmeliet, Dennis E. J. G. J. Dolmans, Rakesh K. Jain, Chae-ok Yun, Carla Mouta Carreira, Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A. Cancer Research. ,vol. 61, pp. 2404- 2408 ,(2001)
Herman D. Suit, Sergey V. Kozin, Daniel J. Hicklin, Yves Boucher, Rakesh K. Jain, Peter Bohlen, Vascular Endothelial Growth Factor Receptor-2-blocking Antibody Potentiates Radiation-induced Long-Term Control of Human Tumor Xenografts Cancer Research. ,vol. 61, pp. 39- 44 ,(2001)
Herman D. Suit, Genevièeve Griffon-Etienne, Christian Brekken, Yves Boucher, Rakesh K. Jain, Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications. Cancer Research. ,vol. 59, pp. 3776- 3782 ,(1999)
Peter Carmeliet, Rakesh K. Jain, Angiogenesis in cancer and other diseases Nature. ,vol. 407, pp. 249- 257 ,(2000) , 10.1038/35025220
Elia Biganzoli, David A. Cheresh, Girolamo Ranieri, Peter B. Vermeulen, Luc Y. Dirix, Rosalba Miceli, Emanuela Bonoldi, Giampietro Gasparini, Peter C. Brooks, Vascular integrin alpha(v)beta3: a new prognostic indicator in breast cancer. Clinical Cancer Research. ,vol. 4, pp. 2625- 2634 ,(1998)
Judah Folkman, Birgit M. Kräling, Catherine E. Butterfield, Blair Marshall, Timothy Browder, Michael S. O’Reilly, Bin Shi, Antiangiogenic Scheduling of Chemotherapy Improves Efficacy against Experimental Drug-resistant Cancer Cancer Research. ,vol. 60, pp. 1878- 1886 ,(2000)
Laura E. Benjamin, Dragan Golijanin, Ahuva Itin, Dov Pode, Eli Keshet, Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal Journal of Clinical Investigation. ,vol. 103, pp. 159- 165 ,(1999) , 10.1172/JCI5028
Erkki Ruoslahti, Targeting tumor vasculature with homing peptides from phage display. Seminars in Cancer Biology. ,vol. 10, pp. 435- 442 ,(2000) , 10.1006/SCBI.2000.0334
Giannoula Klement, Sylvain Baruchel, Janusz Rak, Shan Man, Katherine Clark, Daniel J. Hicklin, Peter Bohlen, Robert S. Kerbel, Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity Journal of Clinical Investigation. ,vol. 105, pp. 2827- 2827 ,(2000) , 10.1172/JCI8829
Rumi Murata, Yasumasa Nishimura, Masahiro Hiraoka, An antiangiogenic agent (TNP-470) inhibited reoxygenation during fractionated radiotherapy of murine mammary carcinoma. International Journal of Radiation Oncology Biology Physics. ,vol. 37, pp. 1107- 1113 ,(1996) , 10.1016/S0360-3016(96)00628-1