Targeting tumor vasculature with homing peptides from phage display.

摘要: Tumor vasculature expresses a number of molecular markers at much lower levels than those seen in the blood vessels normal tissues, and some cases, such are undetectable. The presence these relates to angiogenesis; same shared by all undergoing angiogenesis. endothelial cells, pericytes smooth muscle vascular extracellular matrix angiogenic can each express markers. Molecularly, they represent growth factor receptors, cell adhesion proteins their receptors. Screening phage display libraries for peptides that home tumor when injected into mice has recently provided new tool analyzing distinguishing features vasculature. Tumor-homing isolated this manner, as well an antibody against form fibronectin expressed vessels, have been found serve targeting devices concentrate drugs other therapeutic materials tumors vivo models. Such strategy therefore potentially improve efficacy reduce side effects.