Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

摘要: Features that distinguish tumor vasculatures from normal blood vessels are sought to enable the destruction of preformed vessels. We show in both a xenografted and primary human tumors contain sizable fraction immature have not yet recruited periendothelial cells. These selectively obliterated as consequence vascular endothelial growth factor (VEGF) withdrawal. In glioma, selective vulnerability VEGF loss was demonstrated by downregulating transgene expression using tetracycline-regulated system. prostate cancer, constitutive production glandular epithelium suppressed androgen-ablation therapy. led, turn, apoptosis cells devoid results suggest unique dependence on lacking can be exploited reduce an existing vasculature.