The Maturation of Vessels – A Limitation to Forced Neovascularization?

摘要: Therapeutic angiogenesis is the induction of new blood vessels by delivery appropriate growth factors and an attractive approach to treatment different ischemic conditions. The experience with initial clinical trials in past decade has shown that this may be more complex than anticipated highlights need incorporate current advancements our understanding regulation vessel design novel strategies. generation capillaries from neighboring microvasculature can represented as two-step process: 1) tube formation, which endothelial cells respond gradients angiogenic factors, proliferate migrate towards areas where increased flow needed, 2) vascular maturation, pericytes are recruited proliferating endothelium induce quiescence stabilization through cell-cell contact paracrine factors. formation a network normal morphology physiological function requires proper balance between these two processes.