Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms
作者： Hans-Peter Hammes , Patricia Ann D'Amore , Richard Rohan , Moshe Shani , Mieke Dewerchin
DOI: 10.1172/JCI14362
关键词:
摘要: The murine VEGF gene is alternatively transcribed to yield the VEGF120, VEGF164, and VEGF188 isoforms, which differ in their potential bind heparan sulfate neuropilin-1 stimulate endothelial growth. Here, role retinal vascular development was studied mice selectively expressing single isoforms. VEGF164/164 were normal, healthy, had normal angiogenesis. In contrast, VEGF120/120 exhibited severe defects outgrowth patterning, whereas VEGF188/188 displayed venular but impaired arterial development. It noteworthy that neuropilin-1, a receptor for predominantly expressed arterioles. These findings reveal distinct roles of various isoforms patterning retina.
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