Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A.

摘要: Unlike vascular endothelial growth factor (VEGF)-A, the effect of VEGF-C on tumor angiogenesis, permeability, and leukocyte recruitment is not known. To this end, we quantified in vivo function tumors derived from two VEGF-C-overexpressing (VC + ) mock-transfected cell lines (T241 fibrosarcoma VEGF-A −/− embryonic stem cells) grown murine dorsal skinfold chambers. VC grew more rapidly than exhibited parallel increases angiogenesis. Furthermore, overexpression elevated permeability T241 tumors, but tumors. Surprisingly, unlike VEGF-A, did increase rolling or adhesion vessels. Administration VEGF receptor (VEGFR)-2 neutralizing antibody DC101 reduced density both mock-transduced These data suggest that VEGFR-2 signaling critical for angiogenesis VEGFR-3 does compensate blockade. An alternate VEGFR, VEGFR-1 neuropilin-1, may modulate leukocytes to