Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

作者: Giannoula Klement , Sylvain Baruchel , Janusz Rak , Shan Man , Katherine Clark

DOI: 10.1172/JCI8829

关键词: PharmacologyCombination therapyAngiogenesisVinblastineCancer cellChemotherapyMetronomic ChemotherapyLow-dose chemotherapyVascular endothelial growth factorMedicine

摘要: … as follows: controls, 0.4 mL of PBS and 0.15 mL of saline twice … In contrast, our results suggest that these problems can be … Finally, we would note that there is increasing use of clinical …

参考文章(55)
Angelo Vacca, Monica Iurlaro, Domenico Ribatti, Monica Minischetti, Beatrice Nico, Roberto Ria, Antonio Pellegrino, Franco Dammacco, Antiangiogenesis Is Produced by Nontoxic Doses of Vinblastine Blood. ,vol. 94, pp. 4143- 4155 ,(1999) , 10.1182/BLOOD.V94.12.4143
Tsukasa Matsubara, Kosaku Mizuno, Atsushi Yoshikawa, Ryuichi Saura, A mechanism of cisplatin action: antineoplastic effect through inhibition of neovascularization. The Kobe journal of the medical sciences. ,vol. 43, pp. 109- 120 ,(1997)
R. Pili, A. Passaniti, G. R. Martin, D. S. Grant, R. M. Taylor, P. V. Long, Y. Guo, R. R. Pauly, J. A. Haney, A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Laboratory Investigation. ,vol. 67, pp. 519- 528 ,(1992)
Yoshihiro Kakeji, Beverly A. Teicher, Preclinical studies of the combination of angiogenic inhibitors with cytotoxic agents Investigational New Drugs. ,vol. 15, pp. 39- 48 ,(1997) , 10.1023/A:1005718628223
Robert S. Langer, R. Steiner, Paul B. Weisz, Angiogenesis: Key Principles ― Science ― Technology ― Medicine ,(1992)
Melanie Ehrlich, DNA alterations in cancer : genetic and epigenetic changes Eaton Publishing. ,(2000)
Ian F. Tannock, Shigejiro Hayashi, The Proliferation of Capillary Endothelial Cells Cancer Research. ,vol. 32, pp. 77- 82 ,(1972)
Thomas Boehm, Judah Folkman, Timothy Browder, Michael S. O'Reilly, Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance Nature. ,vol. 390, pp. 404- 407 ,(1997) , 10.1038/37126