摘要: We have recently shown that immunization against the extra domain-B (ED-B) of fibronectin, using Freund's adjuvant, reduces tumor growth in mice by 70%. In present study we compare immune response generated ED-B non-toxic and biodegradable adjuvant Montanide ISA 720/CpG with elicited adjuvant. induced anti-ED-B antibodies higher avidity less variable levels between individuals than Freund's. Moreover, duration was longer generation naive faster, when used. conclude it is possible to replace mineral oil based an acceptable for human use, which a prerequisite transfer vaccine clinic.
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