Tenascin and other adhesion-modulating proteins in cancer.

摘要: A loss in cell-cell adhesion and an increase cell motility are clearly prerequisites for the development of invasive tumors metastasis. Since disseminating tumor cells have to interact with migrate through extracellular matrices it is interest compare composition matrix proteins normal tissues, order determine whether could be critically involved affecting migration. The question will addressed contains increased amounts potentially antiadhesive components behave differently depending on they encounter. results reviewed support hypothesis that changes cellular receptors indeed important process tumorigenesis.