The anti-angiogenic basis of metronomic chemotherapy

摘要: In addition to proliferating cancer cells and various types of normal cells, such as those the bone marrow, conventional cytotoxic chemotherapeutics affect endothelium growing tumour vasculature. The anti-angiogenic efficacy chemotherapy seems be optimized by administering comparatively low doses drug on a frequent or continuous schedule, with no extended interruptions — sometimes referred 'metronomic' chemotherapy. reduced acute toxicity, metronomic increase when administered in combination specific drugs. Gaining better insight into mechanisms these effects could lessen even eliminate empiricism used determine optimal dose schedule for regimens.