UFT and its metabolites inhibit the angiogenesis induced by murine renal cell carcinoma, as determined by a dorsal air sac assay in mice.
作者： Yuji Basaki , Kazutaka Miyadera , Yuji Yamada , Kazuhiko Yonekura , Soko Okabe
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摘要: UFT, an anticancer agent that is composed of tegafur (FT) and uracil at a molar ratio 1:4, widely used in clinical practice Japan to treat cancer patients requiring long-term chemotherapy, it associated with few side effects, if any. In this study, we have evaluated the inhibitory effect UFT against RENCA cell-induced angiogenesis by dorsal air sac assay. Marked induced implantation chamber containing cells into mice. model, showed strong angiogenesis-inhibitory effect, whereas 5-fluorouracil (5-FU) doxifluridine were less effective. Additional experiments revealed FT be effective component UFT; remained ineffective inhibition angiogenesis. Moreover, found γ-hydroxybutyric acid γ-butyrolactone, metabolites FT, possess potent amplified when compounds are administered continuous infusion. This may reflect transition blood concentration each metabolite resulting from administration UFT. Similar results also obtained respect 5-FU. It was suggested has stronger than did other fluorinated pyrimidines, partly due its pharmacokinetic properties characterized maintaining higher long-lasting levels 5-FU effects derived UFT-specific metabolites.
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