Site-directed neovessel formation in vivo

作者: J. Thompson , K. Anderson , J. DiPietro , J. Zwiebel , M Zametta

DOI: 10.1126/SCIENCE.2457952

关键词: Biological activityBiologyNeovascularizationCell biologyOrganogenesisIn vitroBlood vesselAnatomyAngiogenesisCarcinogenesisIn vivo

摘要: Angiogenesis is an important component of organogenesis and wound repair occurs during the pathology oncogenesis, atherogenesis, other disease processes. Thus, it to understand physiological mechanisms that control neovascularization, especially with methods permit molecular dissection phenomenon in vivo. Heparin-binding growth factor-1 was shown bind collagen type I IV. When complexed gelatin, heparin-binding can induce neovascularization at polypeptide concentrations are consistent biological activity mitogen vitro. The adsorption strategy induces rapid blood vessel formation between organ- tissue-specific sites permits recovery site-specific implant for examination manipulation by methods.

参考文章(18)
R Friesel, W H Burgess, T Mehlman, T Maciag, The characterization of the receptor for endothelial cell growth factor by covalent ligand attachment. Journal of Biological Chemistry. ,vol. 261, pp. 7581- 7584 ,(1986) , 10.1016/S0021-9258(19)57433-6
S S Huang, J S Huang, Association of bovine brain-derived growth factor receptor with protein tyrosine kinase activity. Journal of Biological Chemistry. ,vol. 261, pp. 9568- 9571 ,(1986) , 10.1016/S0021-9258(18)67548-9
D Armentano, S F Yu, P W Kantoff, T von Ruden, W F Anderson, E Gilboa, Effect of internal viral sequences on the utility of retroviral vectors. Journal of Virology. ,vol. 61, pp. 1647- 1650 ,(1987) , 10.1128/JVI.61.5.1647-1650.1987
Warren I. Schaeffer, The long-term culture of a diploid rat hepatocyte cell strain. Annals of the New York Academy of Sciences. ,vol. 349, pp. 165- 182 ,(1980) , 10.1111/J.1749-6632.1980.TB29524.X
J. Abraham, A Mergia, J. Whang, A Tumolo, J Friedman, K. Hjerrild, D Gospodarowicz, J. Fiddes, Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor. Science. ,vol. 233, pp. 545- 548 ,(1986) , 10.1126/SCIENCE.2425435
Todd K. Rosengart, Warren V. Johnson, Robert Friesel, Richard Clark, Thomas Maciag, Heparin protects heparin-binding growth factor-I from proteolytic inactivation in vitro Biochemical and Biophysical Research Communications. ,vol. 152, pp. 432- 440 ,(1988) , 10.1016/S0006-291X(88)80732-0
W. H. Burgess, T. Mehlman, D. R. Marshak, B. A. Fraser, T. Maciag, Structural evidence that endothelial cell growth factor beta is the precursor of both endothelial cell growth factor alpha and acidic fibroblast growth factor. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 7216- 7220 ,(1986) , 10.1073/PNAS.83.19.7216
T. Yoshida, K. Miyagawa, H. Odagiri, H. Sakamoto, P. F. Little, M. Terada, T. Sugimura, Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 7305- 7309 ,(1987) , 10.1073/PNAS.84.20.7305
CLIVE DICKSON, GORDON PETERS, Potential oncogene product related to growth factors. Nature. ,vol. 326, pp. 833- 833 ,(1987) , 10.1038/326833A0
Pasquale Delli Bovi, Anna Maria Curatola, Francis G. Kern, Angela Greco, Michael Ittmann, Claudio Basilico, An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family Cell. ,vol. 50, pp. 729- 737 ,(1987) , 10.1016/0092-8674(87)90331-X