γ-Hydroxybutyric acid and 5-fluorouracil, metabolites of UFT, inhibit the angiogenesis induced by vascular endothelial growth factor
作者： Yuji Basaki , Lumi Chikahisa , Kumio Aoyagi , Kazutaka Miyadera , Kazuhiko Yonekura
关键词: Tube formation 、 In vivo 、 DNA synthesis 、 Angiogenesis 、 Vascular endothelial growth factor 、 In vitro 、 Umbilical vein 、 Cell culture 、 Biochemistry 、 Biology 、 Pharmacology
摘要: … the chemotactic migration and tube formation, but not … tube formation of HUVECs. However, these effects were associated with the inhibition of DNA synthesis as determined by BrdU …
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Yuji Basaki, Kazutaka Miyadera, Yuji Yamada, Kazuhiko Yonekura, Soko Okabe, Konstanty Wierzba, Lumi Chikahisa, Akihiro Hashimoto, UFT and its metabolites inhibit the angiogenesis induced by murine renal cell carcinoma, as determined by a dorsal air sac assay in mice. Clinical Cancer Research. ,vol. 5, pp. 2185- 2191 ,(1999)
J Lai-Sim Au, Wolfgang Sadée, None, Activation of Ftorafur [R,S-1-(Tetrahydro-2-furanyl)-5-fluorouracil] to 5-Fluorouracil and γ-Butyrolactone Cancer Research. ,vol. 40, pp. 2814- 2819 ,(1980)
G. Breier, B. Millauer, A. Ullrich, W. Risau, K. H. Plate, Up-Regulation of Vascular Endothelial Growth Factor and Its Cognate Receptors in a Rat Glioma Model of Tumor Angiogenesis Cancer Research. ,vol. 53, pp. 5822- 5827 ,(1993)
Daniel E. Johnson, Lewis T. Williams, Structural and Functional Diversity in the FGf Receptor Multigene Family Advances in Cancer Research. ,vol. 60, pp. 1- 41 ,(1992) , 10.1016/S0065-230X(08)60821-0
Ayako Yukita, Hideo Suzuki, Shinichi Kondo, Makoto Asano, Tomoe Matsumoto, Inhibition of Tumor Growth and Metastasis by an Immunoneutralizing Monoclonal Antibody to Human Vascular Endothelial Growth Factor/Vascular Permeability Factor121 Cancer Research. ,vol. 55, pp. 5296- 5301 ,(1995)
Debra Weinstat‐Saslow, Patricia S. Steeg, Angiogenesis and colonization in the tumor metastatic process: basic and applied advances. The FASEB Journal. ,vol. 8, pp. 401- 407 ,(1994) , 10.1096/FASEBJ.8.6.7513289
TERUYOSHI MARUNAKA, YOSHINORI MINAMI, YUKIHIKO UMENO, AKIO YASUDA, TOSHIYUKI SATO, SETSURO FUJII, Identification of metabolites of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT-207) formed in vitro by rat liver microsomes. Chemical & Pharmaceutical Bulletin. ,vol. 28, pp. 1795- 1803 ,(1980) , 10.1248/CPB.28.1795
Corazon D. Bucana, Yasuhiko Kitadai, Karen R. Cleary, Lee M. Ellis, Yutaka Takahashi, Expression of Vascular Endothelial Growth Factor and Its Receptor, KDR, Correlates with Vascularity, Metastasis, and Proliferation of Human Colon Cancer Cancer Research. ,vol. 55, pp. 3964- 3968 ,(1995)
Steven A. Stacker, Mary Saleh, Andrew F. Wilks, Inhibition of Growth of C6 Glioma Cells in Vivo by Expression of Antisense Vascular Endothelial Growth Factor Sequence Cancer Research. ,vol. 56, pp. 393- 401 ,(1996)
T Shibusa, N Shijubo, S Abe, Tumor angiogenesis and vascular endothelial growth factor expression in stage I lung adenocarcinoma. Clinical Cancer Research. ,vol. 4, pp. 1483- 1487 ,(1998)