Myeloid-Derived Suppressor Cells and Therapeutic Strategies in Cancer.

摘要: Development of solid cancer depends on escape from host immunosurveillance. Various types immune cells contribute to tumor-induced suppression, including tumor associated macrophages, regulatory T cells, type 2 NKT and myeloid-derived suppressor (MDSCs). Growing body evidences shows that MDSCs play pivotal roles among these immunosuppressive in multiple steps progression. are immature myeloid arise progenitor comprise a heterogeneous cell population. characterized by the ability suppress both adaptive innate immunities mainly through direct inhibition cytotoxic functions NK cells. In clinical settings, number circulating is with stages response treatment several cancers. Moreover, reported chemoresistant phenotype. Collectively, targeting could potentially provide rationale for novel strategies cancer. This review summarizes recent understandings discusses promissing approaches patients.