Mesenchymal Transition and Dissemination of Cancer Cells Is Driven by Myeloid-Derived Suppressor Cells Infiltrating the Primary Tumor

摘要: In order to metastasize, cancer cells need acquire a motile phenotype. Previously, development of this phenotype was thought rely on the acquisition selected, random mutations and thus would occur late in progression. However, recent studies show that disseminate early, implying existence different, faster route metastatic Using spontaneous murine model melanoma, we subset bone marrow-derived immune (myeloid-derived suppressor or MDSC) preferentially infiltrates primary tumor actively promotes cell dissemination by inducing epithelial-mesenchymal transition (EMT). CXCL5 is main chemokine attracting MDSC tumor. vitro assay using purified showed TGF-β, EGF, HGF signaling pathways are all used induce EMT cells. These findings explain how so early provide mechanistic explanation for long recognized link between inflammation