Autochthonous primary and metastatic melanomas in Hgf-Cdk4R24C mice evade T-cell-mediated immune surveillance

摘要: Summary Genetically engineered mouse models offer new opportunities to investigate the role of cell-mediated immunity in natural progression melanoma an immunocompetent host. Here we report that Hgf-Cdk4R24C mice spontaneously develop a spectrum primary melanomas with high penetrance during their first year life. Malignant transformation proceeds stepwise manner from multiple melanocytic nevi single nodular and disseminated metastases most mice. Migrating cells invade draining lymph nodes without activating immune system. Autochthonous tumors are destroyed following experimental introduction surveillance using adoptive lymphocyte transfer approach. However, some tumor able survive, evade cell control, recur both locally systemically. Immune tolerance recurring may be supported by immunosuppressive Gr1+ myeloid cells. Taken together, our results demonstrate metastatic developing effectively cellular surveillance.