T cell immunotherapy for melanoma from bedside to bench to barn and back: how conceptual advances in experimental mouse models can be translated into clinical benefit for patients

摘要: Summary A solid scientific basis now supports the concept that cytotoxic T lymphocytes can specifically recognize and destroy melanoma cells. Over last decades, clinicians basic scientists have joined forces to advance our concepts of immunobiology. This has catalyzed rational development therapeutic approaches enforce melanoma-specific cell responses. Preclinical studies in experimental mouse models paved way for their successful translation into clinical benefit patients with metastatic melanoma. A more thorough understanding how melanomas develop resistance immunotherapy is necessary extend this success. requires a continued interdisciplinary effort biologists immunologists closely connects observations vitro investigations appropriate vivo models: From bedside bench barn back.