Plasticity of tumour and immune cells: a source of heterogeneity and a cause for therapy resistance?

作者: Michael Hölzel , Anton Bovier , Thomas Tüting

DOI: 10.1038/NRC3498

关键词: BiologyMelanomaSignal transductionCancerCancer researchInflammationImmunotherapyTumor microenvironmentImmune systemImmunologyMechanism (biology)

摘要: … cell proliferation, differentiation and death 1 . Genetically and phenotypically heterogeneous malignant cells … with abnormal fibroblasts, endothelial cells and immune cells in the tumour …

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