Modelling melanoma in mice.

摘要: Phenotypic and molecular heterogeneity in human melanoma has impaired efforts to explain many of the clinically important features melanoma. For example, underlying mechanisms that might predict age-of-onset, time metastasis other key elements progression remain unknown. Furthermore, staging used outcome treatment not yet moved beyond a basic phenotypic classification. While molecularly targeted therapies show great promise for patients, establishing accurate animal models recapitulate cutaneous remains priority. We examine relevance mice as histopathologic variants These may be preclinical probe relationships between causative mutations, disease therapeutics. ask how new mouse models, or more detailed analyses existing advance our understanding genotype-phenotype correlations this tumour type. This necessarily involves consideration utility ultraviolet radiation-induced melanoma, improved.