Bv8 regulates myeloid-cell-dependent tumour angiogenesis
作者： Farbod Shojaei , Xiumin Wu , Cuiling Zhong , Lanlan Yu , Xiao-Huan Liang
DOI: 10.1038/NATURE06348
关键词:
摘要: Bone-marrow-derived cells facilitate tumour angiogenesis, but the molecular mechanisms of this facilitation are incompletely understood. We have previously shown that related EG-VEGF and Bv8 proteins, also known as prokineticin 1 (Prok1) 2 (Prok2), promote both tissue-specific angiogenesis haematopoietic cell mobilization. Unlike EG-VEGF, is expressed in bone marrow. Here we show implantation mice resulted upregulation CD11b+Gr1+ myeloid cells. identified granulocyte colony-stimulating factor a major positive regulator expression. Anti-Bv8 antibodies reduced mobilization elicited by factor. Adenoviral delivery into tumours was to angiogenesis. inhibited growth several suppressed treatment cells, peripheral blood tumours. The effects anti-Bv8 were additive those anti-Vegf or cytotoxic chemotherapy. Thus, modulates from marrow during development promotes locally.
nature.com
harvard.edu
sci-hub.se 参考文章(44)
S Neben, K Marcus, P Mauch, Mobilization of Hematopoietic Stem and Progenitor Cell Subpopulations From the Marrow to the Blood of Mice Following Cyclophosphamide and/or Granulocyte Colony-Stimulating Factor Blood. ,vol. 81, pp. 1960- 1967 ,(1993) , 10.1182/BLOOD.V81.7.1960.1960
Jennifer LeCouter, Joe Kowalski, Jessica Foster, Phil Hass, Zemin Zhang, Lisa Dillard-Telm, Gretchen Frantz, Linda Rangell, Leo DeGuzman, Gilbert-Andre Keller, Franklin Peale, Austin Gurney, Kenneth J. Hillan, Napoleone Ferrara, Identification of an angiogenic mitogen selective for endocrine gland endothelium Nature. ,vol. 412, pp. 877- 884 ,(2001) , 10.1038/35091000
Gabriele Bergers, Rolf Brekken, Gerald McMahon, Thiennu H. Vu, Takeshi Itoh, Kazuhiko Tamaki, Kazuhiko Tanzawa, Philip Thorpe, Shigeyoshi Itohara, Zena Werb, Douglas Hanahan, Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis Nature Cell Biology. ,vol. 2, pp. 737- 744 ,(2000) , 10.1038/35036374
M. Li, C. M. Bullock, D. J. Knauer, F. J. Ehlert, Q. Y. Zhou, Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle. Molecular Pharmacology. ,vol. 59, pp. 692- 698 ,(2001) , 10.1124/MOL.59.4.692
Lisa M. Coussens, Zena Werb, Inflammation and cancer Nature. ,vol. 420, pp. 860- 867 ,(2002) , 10.1038/NATURE01322
H. Nozawa, C. Chiu, D. Hanahan, Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 12493- 12498 ,(2006) , 10.1073/PNAS.0601807103
Richard Dahl, Jonathan C Walsh, David Lancki, Peter Laslo, Sangeeta R Iyer, Harinder Singh, M Celeste Simon, Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPα ratio and granulocyte colony-stimulating factor Nature Immunology. ,vol. 4, pp. 1029- 1036 ,(2003) , 10.1038/NI973
Peter Carmeliet, Angiogenesis in health and disease. Nature Medicine. ,vol. 9, pp. 653- 660 ,(2003) , 10.1038/NM0603-653
Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouter, None, The biology of VEGF and its receptors. Nature Medicine. ,vol. 9, pp. 669- 676 ,(2003) , 10.1038/NM0603-669
Marion Dorsch, Yubin Qiu, Dulce Soler, Nita Frank, Thao Duong, Andrew Goodearl, Steve O’Neil, Jose Lora, Christopher C. Fraser, PK1/EG-VEGF induces monocyte differentiation and activation. Journal of Leukocyte Biology. ,vol. 78, pp. 426- 434 ,(2005) , 10.1189/JLB.0205061