Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
作者： Gabriele Bergers , Rolf Brekken , Gerald McMahon , Thiennu H. Vu , Takeshi Itoh
DOI: 10.1038/35036374
关键词: Downregulation and upregulation 、 Cell biology 、 Vascular endothelial growth factor A 、 Matrix metalloproteinase 、 Pancreatic islets 、 Biology 、 Signal transduction 、 Angiogenic Switch 、 Vascular endothelial growth factor 、 Angiogenesis
摘要: During carcinogenesis of pancreatic islets in transgenic mice, an angiogenic switch activates the quiescent vasculature. Paradoxically, vascular endothelial growth factor (VEGF) and its …
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