Chapter 2 Managing Tumor Angiogenesis. Lessons from VEGF-Resistant Tumors and Wounds

摘要: It is now well established both experimentally and clinically, that new blood vessel growth required for tumors to grow beyond a few millimeters metastasize [Folkman, J. (1995). In: Mendelsohn, L., Howley, P., Israel, A. (Eds.), The Molecular Basis of Cancer, WB Saunders Company, Philadelphia, pp. 206-225]. Angiogenesis, the process forming vessels from preexisting vessels, provides tumor with additional oxygen nutrients its continued growth. In addition, proximity increase in vascular density enhance likelihood cells entering bloodstream eventually metastasize. Since initial observations Dr. Folkman late 1970s, research over past 30 years has focused intensely on identifying points which angiogenic cycle can be disrupted become an important component current therapies limit progression.