Biomechanical regulation of blood vessel growth during tissue vascularization.

摘要: Formation of new vessels in granulation tissue during wound healing has been assumed to occur solely through sprouting angiogenesis. In contrast, we show here that neovascularization can be accomplished by nonangiogenic expansion preexisting vessels. Using models based on the chick chorioallantoic membrane and mouse cornea, found tension generated activated fibroblasts or myofibroblasts contraction mediated directed translocation vasculature. These mechanical forces pulled from vascular bed as loops with functional circulation expanded an integral part growing vessel enlargement elongation. Blockade endothelial growth factor receptor-2 confirmed biomechanical were sufficient mediate initial independently proliferation. The neovascular network was further remodeled splitting, regression individual This model explains rapid appearance large healing.