Myeloid derived suppressor cells—An overview of combat strategies to increase immunotherapy efficacy
作者： Oana Draghiciu , Joyce Lubbers , Hans W Nijman , Toos Daemen
DOI: 10.4161/21624011.2014.954829
关键词: Myeloid-derived Suppressor Cell 、 Blockade 、 Cancer 、 Gemcitabine 、 Immunology 、 Biology 、 Suppressor 、 Immunotherapy 、 In vivo 、 Cytotoxic T cell
摘要: Myeloid-derived suppressor cells (MDSCs) contribute to tumor-mediated immune escape and negatively correlate with overall survival of cancer patients. Nowadays, a variety methods target MDSCs are being investigated. Based on the intervention stage MDSCs, namely development, expansion activation, function turnover, these can be divided into: (I) prevention or differentiation mature cells, (II) blockade MDSC (III) inhibition suppressive activity (IV) depletion intratumoral MDSCs. This review describes effective mono- multimodal-therapies that for benefit treatment.
core.ac.uk
narcis.nl参考文章(79)
M Valtieri, E Tritarelli, R Masciulli, R Martucci, A Camagna, U Testa, T Barberi, G Mariani, C Peschle, R Pustorino, Transforming growth factor-beta potentiates vitamin D3-induced terminal monocytic differentiation of human leukemic cell lines. Journal of Immunology. ,vol. 150, pp. 2418- 2430 ,(1993)
Randy D’Amico, Liang Lei, Benjamin C Kennedy, Julia Sisti, Victoria Ebiana, Celina Crisman, James G Christensen, Orlando Gil, Steven S Rosenfeld, Peter Canoll, Jeffrey N Bruce, The addition of Sunitinib to radiation delays tumor growth in a murine model of glioblastoma Neurological Research. ,vol. 34, pp. 252- 261 ,(2012) , 10.1179/1743132812Y.0000000005
You Kawarada, Ruth Ganss, Natalio Garbi, Torsten Sacher, Bernd Arnold, Günter J. Hämmerling, NK- and CD8(+) T cell-mediated eradication of established tumors by peritumoral injection of CpG-containing oligodeoxynucleotides. Journal of Immunology. ,vol. 167, pp. 5247- 5253 ,(2001) , 10.4049/JIMMUNOL.167.9.5247
Amit A. Lugade, James P. Moran, Scott A. Gerber, Robert C. Rose, John G. Frelinger, Edith M. Lord, Local Radiation Therapy of B16 Melanoma Tumors Increases the Generation of Tumor Antigen-Specific Effector Cells That Traffic to the Tumor Journal of Immunology. ,vol. 174, pp. 7516- 7523 ,(2005) , 10.4049/JIMMUNOL.174.12.7516
Takeshi Kuwata, I-Ming Wang, Tomohiko Tamura, Roshini M. Ponnamperuma, Rachel Levine, Kevin L. Holmes, Herbert C. Morse, Luigi M. De Luca, Keiko Ozato, Vitamin A deficiency in mice causes a systemic expansion of myeloid cells Blood. ,vol. 95, pp. 3349- 3356 ,(2000) , 10.1182/BLOOD.V95.11.3349.011K46_3349_3356
Sergei Kusmartsev, Yulia Nefedova, Daniel Yoder, Dmitry I. Gabrilovich, Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species. Journal of Immunology. ,vol. 172, pp. 989- 999 ,(2004) , 10.4049/JIMMUNOL.172.2.989
Erica M. Hanson, Virginia K. Clements, Pratima Sinha, Dan Ilkovitch, Suzanne Ostrand-Rosenberg, Myeloid-Derived Suppressor Cells Down-Regulate L-Selectin Expression on CD4+ and CD8+ T Cells Journal of Immunology. ,vol. 183, pp. 937- 944 ,(2009) , 10.4049/JIMMUNOL.0804253
Bond Almand, Joseph I. Clark, Ekaterina Nikitina, James van Beynen, Nicholas R. English, Stella C. Knight, David P. Carbone, Dmitry I. Gabrilovich, Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer. Journal of Immunology. ,vol. 166, pp. 678- 689 ,(2001) , 10.4049/JIMMUNOL.166.1.678
Susanna Mandruzzato, Samantha Solito, Erika Falisi, Samuela Francescato, Vanna Chiarion-Sileni, Simone Mocellin, Antonio Zanon, Carlo R. Rossi, Donato Nitti, Vincenzo Bronte, Paola Zanovello, IL4Rα+ Myeloid-Derived Suppressor Cell Expansion in Cancer Patients Journal of Immunology. ,vol. 182, pp. 6562- 6568 ,(2009) , 10.4049/JIMMUNOL.0803831
Sergei Kusmartsev, Evgeniy Eruslanov, Hubert Kübler, Timothy Tseng, Yoshihisa Sakai, Zhen Su, Sergei Kaliberov, Axel Heiser, Charles Rosser, Philip Dahm, Dietmar Siemann, Johannes Vieweg, Oxidative Stress Regulates Expression of VEGFR1 in Myeloid Cells: Link to Tumor-Induced Immune Suppression in Renal Cell Carcinoma Journal of Immunology. ,vol. 181, pp. 346- 353 ,(2008) , 10.4049/JIMMUNOL.181.1.346