Vitamin A deficiency in mice causes a systemic expansion of myeloid cells

摘要: To examine the role of retinoids in hematopoietic cell growth vivo, we studied female SENCAR mice made vitamin A deficient by dietary restriction. Deficient exhibited a dramatic increase myeloid cells bone marrow, spleen, and peripheral blood. The abnormal expansion was detected from an early stage deficiency contrasted with essentially normal profiles T B lymphocytes. This abnormality reversed on addition retinoic acid to A-deficient diet, indicating that is direct result deficiency. TUNEL analysis indicated spontaneous apoptosis, process life cycle cells, impaired mice, which may play increased population. Quantitative reverse transcriptase-polymerase chain reaction purified granulocytes showed expression not only RAR, but RXRs, 2 nuclear receptors mediate biologic activities retinoids, significantly reduced mice. work shows critically control homeostasis population vivo suggests this signaling pathway contribute various myeloproliferative disorders.