Constitutive activation of Raf-1 induces glioma formation in mice.
作者： Yelena Lyustikman , Hiroyuki Momota , William Pao , Eric C. Holland
DOI: 10.1593/NEO.08206
关键词:
摘要: … gliomas similar to activated KRas under the same conditions. Our study suggests that the oncogenic effect of KRas in glioma … of this pathway may be beneficial in glioma treatment. …
core.ac.uk 
sci-hub.se 参考文章(45)
Eric C. Holland, Gliomagenesis: genetic alterations and mouse models Nature Reviews Genetics. ,vol. 2, pp. 120- 129 ,(2001) , 10.1038/35052535
Karlyne M. Reilly, Dagan A. Loisel, Roderick T. Bronson, Margaret E. McLaughlin, Tyler Jacks, Nf1 ; Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects Nature Genetics. ,vol. 26, pp. 109- 113 ,(2000) , 10.1038/79075
Lene Uhrbom, Eric C. Holland, Modeling Gliomagenesis with Somatic Cell Gene Transfer using Retroviral Vectors Journal of Neuro-oncology. ,vol. 53, pp. 297- 305 ,(2001) , 10.1023/A:1012208314436
K Ichimura, Maria Bondesson Bolin, Helena M Goike, Esther E Schmidt, Ahmad Moshref, V Peter Collins, Deregulation of the p14ARF/MDM2/p53 Pathway Is a Prerequisite for Human Astrocytic Gliomas with G1-S Transition Control Gene Abnormalities Cancer Research. ,vol. 60, pp. 417- 424 ,(2000)
Paul Kleihues, David N. Louis, Bernd W. Scheithauer, Lucy B. Rorke, Guido Reifenberger, Peter C. Burger, Webster K. Cavenee, The WHO Classification of Tumors of the Nervous System Journal of Neuropathology and Experimental Neurology. ,vol. 61, pp. 215- 225 ,(2002) , 10.1093/JNEN/61.3.215
Jana Karaskova, David H. Gutmann, Luba Roncari, Luba Roncari, Patrick Shannon, Andras Nagy, Abhijit Guha, Abhijit Guha, Abhijit Guha, Jeremy A. Squire, Xiaoli Wu, Nelson Lau, Nelson Lau, Hao Ding, Astrocyte-specific Expression of Activated p21-ras Results in Malignant Astrocytoma Formation in a Transgenic Mouse Model of Human Gliomas Cancer Research. ,vol. 61, pp. 3826- 3836 ,(2001)
V P Stanton, D W Nichols, A P Laudano, G M Cooper, Definition of the human raf amino-terminal regulatory region by deletion mutagenesis. Molecular and Cellular Biology. ,vol. 9, pp. 639- 647 ,(1989) , 10.1128/MCB.9.2.639
Eric C. Holland, Gregory N. Fuller, Lene Uhrbom, Marc K. Rosenblum, Joseph C. Celestino, Chengkai Dai, Ink4a-Arf Loss Cooperates with KRas Activation in Astrocytes and Neural Progenitors to Generate Glioblastomas of Various Morphologies Depending on Activated Akt Cancer Research. ,vol. 62, pp. 5551- 5558 ,(2002)
Edna T Kimura, Marina N Nikiforova, Zhaowen Zhu, Jeffrey A Knauf, Yuri E Nikiforov, James A Fagin, None, High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Research. ,vol. 63, pp. 1454- 1457 ,(2003)
Patrick Shannon, Nesrin Sabha, Nelson Lau, Deepak Kamnasaran, David H. Gutmann, Abhijit Guha, Pathological and Molecular Progression of Astrocytomas in a GFAP:12V-Ha-Ras Mouse Astrocytoma Model American Journal of Pathology. ,vol. 167, pp. 859- 867 ,(2005) , 10.1016/S0002-9440(10)62057-3