Migration pathways of human glioblastoma cells xenografted into the immunosuppressed rat brain.

摘要: Diffuse invasion of the brain by tumor cells is a hallmark human glioblastomas and major cause for poor prognosis these tumors. This phenomenon only partially reproduced rodent models gliomas that display very high rate proliferation limited cell migration. We have analyzed development glioblastoma (GL15) xenografted into immunosuppressed rats, in order to define characteristics invasion. As identified specific immunolabeling HLA-ABC antigen, GL15 tumors three types intraparenchymal observed patients. First, majority multipolar intermingled rapidly profusely with host neural margin injection site. progressively enlarging area was principally responsible growth over time. Second, gray matter, columns thin bipolar aligned along capillary walls. Third, white elongated isolated were scattered between axonal fibers. The maximum migration distances matter fibers remained significantly higher than blood vessels, up two months after injection. Development associated significant increase vascularization spread. Xenografting rat allowed differentiate classical clinic, quantify precisely migration, evaluate morphology each routes. present results support existence host/tumor interactions type