Dynamic Contrast Enhancement of Experimental Glioma

摘要: Rationale and Objectives The aim of this study was to compare tumor signal contrast media uptake characteristics on contrast-enhanced T1-weighted sequences at 3 Tesla over 30 minutes after double-dose administration different agents in an animal model brain glioma. Materials Methods Nine rats underwent magnetic resonance imaging (MRI) stereotactic F98 glioma cell implantation before repetitively for injection gadobutrol, gadopentetate, gadobenate, respectively. Signal-to-noise ratio (SNR) contrast-to-noise (CNR) were evaluated MRI-derived volumes compared histology. Results Postcontrast SNR CNR peaked 4 application. While contrast-enhancement within the fading, volume increased by continuous contrast-uptake peripheral parts between (137 ± 29 mm3, 126 16 141 24 mm3) 20 (182 35 164 32 191 25 mm3), At 8 12 minutes, 84% 91% definable, Conclusion Optimal correlation histology is achieved up (this delay mostly used clinical routine), only 75% enhancing assessable. A already reveals seems be a practical compromise.