MRI assessment of experimental gliomas using 17.6 T

摘要: Using ultra-high-field contrast-enhanced magnetic resonance imaging (MRI), an increase of field strength is associated with a decrease T 1 relaxivity. Yet, the impact this effect on signal characteristics and pathology remains unclear. Hence, we evaluated potential 17.6-T MRI to assess contrast-enhancing parts experimentally induced rat gliomas compared 3 T. A total eight tumor-bearing rats were used for assessments either at 17.6 T (four rats) or 3 T 11 days after stereotactic implantation F98 glioma cells into right frontal lobe. 1-weighted sequences investigate signal-to-noise-ratios, contrast-to-noise-ratios, relative contrast enhancement up 16 min double-dose application. In addition, tumor volumes calculated histology. The 17.6-T-derived 31.5 ± 15.4 mm3 4 min, 38.8 ± 12.7 mm3 8 min, 51.1 ± 12.6 mm3 12 min, 61.5 ± 10.8 mm3 gadobutrol injection. Corresponding histology-derived clearly higher (138.8 ± 8.4 mm3; P < 0.01). At 3 T, 85.2 ± 11.7 mm3 107.3 ± 11.0 mm3 117.0 ± 10.5 mm3 129.1 ± 10.0 mm3 agent Averaged (139.1 ± 13.4 mm3) in group comparable 16-min volume (P ↔16 min = 0.38). Compared MRI, all 3-T-derived significantly (P < 0.02). images histology, underestimated by approximately 50 % 17.6 T. provided no further benefits measurement