In vivo transfer of the human interleukin-2 gene: negative tumoricidal results in experimental brain tumors

摘要: ✓ The authors have recently shown the feasibility of eradicating brain tumors using in vivo retroviral-mediated transduction with herpes simplex thymidine kinase (HStk) gene and ganciclovir therapy. However, kinase-transduced subcutaneous immunocompromised (athymic) mice were less responsive to this therapy than immunocompetent animals, suggesting a role immune system process tumor eradication. Broad suppression humoral cell-mediated immunity is found patients malignant gliomas. Interleukin-2 (IL-2) production IL-2 receptor expression are decreased glioma patients. These findings proposed association between lymphocytic infiltration survival suggest that response modifiers may be useful treating To evaluate local cytokine by cells, alone or combined HStk transfer therapy, investigated efficacy (9L ...