Depressed cell-mediated immunity in patients with primary intracranial tumors. Characterization of a humoral immunosuppressive factor.

摘要: Tumor immunity in patients with primary intracranial tumors was assessed relation to the general status of host immunocompetence. Lymphocyte sensitization tumor-specific membrane antigens demonstrated by proliferative response lymphocytes presence autochthonous tumor cells. Paradoxically, one-half could not be sensitized a antigen, dinitrochlorobenzene; existing delayed hypersensitivity also depressed, as measured skin tests and lymphocyte transformation common antigens. A heat-stable factor patients' sera blocked cell-mediated immunity. In addition, these "enhancing" consistently suppressed blastogenic autologous homologous phytohemagglutinin on allogeneic cells one-way mixed culture. When leukocytes were washed plasma replaced normal plasma, reactivity culture increased values. vitro immunosuppressive activity or correlated depressed hypersensitivity. After removal tumor, suppressor disappeared. IgG fractions patient contained strong activity. These data suggest that may an isoantibody elicited binds receptors membrane. addition specifically blocking immunity, enhancing broadly depress