Gene therapy for tumors using minus-strand RNA viral vectors encoding immunostimulatory cytokines

作者: Akira Yamaura , Mamoru Hasegawa , Yasuo Iwadate , Makoto Inoue

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摘要: The present invention provides methods for treating tumors, which comprise the step of administering into tumor sites a minus-strand RNA viral vector encoding an immunostimulatory cytokine or cells introduced with vector. also compositions as active ingredient kits cytokine, and antigen expressing antigen.

参考文章(70)
Nicholas Miller, Richard Vile, Targeted vectors for gene therapy. The FASEB Journal. ,vol. 9, pp. 190- 199 ,(1995) , 10.1096/FASEBJ.9.2.7781922
Haruo Onda, Kyozo Tsukamoto, Shuji Hinuma, Messenger RNA, production and use thereof ,(1982)
Ronald C. Montelaro, Olivera J. Finn, J. Darrell Fontenot, Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof ,(1994)
Yasuo Iwadate, Hiroki Namba, Masatoshi Tagawa, Keizo Takenaga, Kanji Sueyoshi, Shigeru Sakiyama, Induction of acquired immunity in rats that have eliminated intracranial gliosarcoma cells by the expression of herpes simplex virus-thymidine kinase gene and ganciclovir administration. Oncology. ,vol. 54, pp. 329- 334 ,(1997) , 10.1159/000227712
Michael Bitzer, Sorin Armeanu, Ulrich M. Lauer, Wolfgang J. Neubert, Sendai virus vectors as an emerging negative-strand RNA viral vector system Journal of Gene Medicine. ,vol. 5, pp. 543- 553 ,(2003) , 10.1002/JGM.426
Makoto Inoue, Yumiko Tokusumi, Hiroshi Ban, Masayuki Shirakura, Takumi Kanaya, Mariko Yoshizaki, Takashi Hironaka, Yoshiyuki Nagai, Akihiro Iida, Mamoru Hasegawa, Recombinant Sendai virus vectors deleted in both the matrix and the fusion genes: efficient gene transfer with preferable properties Journal of Gene Medicine. ,vol. 6, pp. 1069- 1081 ,(2004) , 10.1002/JGM.597
J. H. Sampson, G. E. Archer, D. M. Ashley, H. E. Fuchs, L. P. Hale, G. Dranoff, D. D. Bigner, Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 10399- 10404 ,(1996) , 10.1073/PNAS.93.19.10399
Efstathios J. Boviatsis, Maureen Chase, Ming X. Wei, Takashi Tamiya, Robert K. Hurford, Neil W. Kowall, Robert I. Tepper, Xandra O. Breakefield, E. Antonio Chiocca, Gene Transfer into Experimental Brain Tumors Mediated by Adenovirus, Herpes Simplex Virus, and Retrovirus Vectors Human Gene Therapy. ,vol. 5, pp. 183- 191 ,(1994) , 10.1089/HUM.1994.5.2-183
Gail Ross, Robert Erickson, Debra Knorr, Arno G. Motulsky, Robertson Parkman, Jude Samulski, Stephen E. Straus, Brian R. Smith, Gene Therapy in the United States: A Five-Year Status Report Human Gene Therapy. ,vol. 7, pp. 1781- 1790 ,(1996) , 10.1089/HUM.1996.7.14-1781