The differential inhibitory effects exerted by cyclosporine and hydrocortisone on the activation of human cytotoxic lymphocytes by recombinant interleukin-2 versus allospecific CTL.

摘要: Two immunosuppressive drugs, cyclosporine (CsA) and Hydrocortisone (Hy) were examined in parallel for their effect on the generation of cytolytic T lymphocytes (CTL). Peripheral blood (PBL) stimulated with allogeneic cells to produce allospecific CTL, or purified recombinant Interleukin 2 activate lymphokine activated killer (LAK). CTL LAK activity measured a 4 hr chromium release assay after 7 days activation. Lysis by was tested against stimulator PBL (not blasts) fresh sarcoma tumor cells. At pharmacologic doses, CsA inhibited only generation, Hy LAK. This greater understanding selective role, roles, vitro provides basis which consider immune suppression--and, alternatively, possibility combining modalities more thorough suppression.