Influence of PGE2- and cAMP-modulating agents on human glioblastoma cell killing by interleukin-2-activated lymphocytes.
作者： Maria C. Kuppner , Yutaka Sawamura , Marie-France Hamou , Nicolas de Tribolet
DOI: 10.3171/JNS.1990.72.4.0619
关键词: Tumor-infiltrating lymphocytes 、 Lymphokine-activated killer cell 、 Cancer research 、 Intracellular 、 Interleukin 2 、 Glioma 、 Biology 、 Immunology 、 Cyclic adenosine monophosphate 、 Transforming growth factor beta 、 Cytotoxicity
摘要: ✓ Human glioblastoma cells secrete factors, such as prostaglandin E (PGE) and transforming growth factor beta type 2, which are capable of suppressing several immune functions. The present study investigated the effect PGE2 agents known to increase intracellular cyclic adenosine monophosphate (cAMP) levels on 1) induction lymphokine-activated killer (LAK) cell activity from peripheral blood lymphocytes (PBL) both normal glioma patients 2) cytolytic activities tumor-infiltrating (TIL's) isolated malignant gliomas after expansion in vitro with interleukin-2 (IL-2). Cytolytic was measured against autologous allogeneic tumor natural killer-resistant Daudi line. results demonstrate that cAMP can significantly suppress IL-2-dependent generation PBL glioblastoma-derived TIL's. inhibitory eff...
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