Mechanisms of immune evasion by gliomas.

作者: Cleo E. Rolle , Sadhak Sengupta , Maciej S. Lesniak

DOI: 10.1007/978-1-4614-3146-6_5

关键词: Interleukin 10Cancer researchTumor EscapeBiologyImmunityGliomaMicrogliaImmune systemImmune toleranceAntigen-presenting cell

摘要: A major contributing factor to glioma development and progression is its ability evade the immune system. This chapter will explore mechanisms utilized by mediate immunosuppression evasion. These include intrinsic linked location within brain interactions between cells cells. Lack of recruitment naive effector perhaps accounts for most suppression mediated these tumor enhanced increased microglia which resemble immature antigen presenting that are unable support T-cell immunity. Furthermore, secreted factors like TGF-β, COX-2 IL-10, altered costimulatory molecules inhibition STAT-3 all contribute expansion regulatory T cells, further modulate immunosuppressive environment glioma. In light findings, multiple immunotherapeutic treatment modalities currently being explored.

参考文章(214)
Namita Kundu, Amy M Fulton, Selective Cyclooxygenase (COX)-1 or COX-2 Inhibitors Control Metastatic Disease in a Murine Model of Breast Cancer Cancer Research. ,vol. 62, pp. 2343- 2346 ,(2002)
Hyun-Ock Pae, Gi-Su Oh, Byung-Min Choi, Soo-Cheon Chae, Young-Myeong Kim, Khee-Rhin Chung, Hun-Taeg Chung, Carbon Monoxide Produced by Heme Oxygenase-1 Suppresses T Cell Proliferation via Inhibition of IL-2 Production Journal of Immunology. ,vol. 172, pp. 4744- 4751 ,(2004) , 10.4049/JIMMUNOL.172.8.4744
Avi Ashkenazi, Wolfgang Wick, Hiroko Ohgaki, Mathias Bähr, Stefan Isenmann, Michael Platten, Michael Weller, Mitsutoshi Nakamura, Paul Kleihues, Wilfried Roth, Soluble decoy receptor 3 is expressed by malignant gliomas and suppresses CD95 ligand-induced apoptosis and chemotaxis. Cancer Research. ,vol. 61, pp. 2759- 2765 ,(2001)
Etty N. Benveniste, Jae-Wook Oh, Chulhee Choi, Hanjoong Jo, Xiang Xu, Sung Joong Lee, G. Yancey Gillespie, Heonyong Park, Fas-induced Expression of Chemokines in Human Glioma Cells Involvement of Extracellular Signal-regulated Kinase 1/2 and p38 Mitogen-activated Protein Kinase Cancer Research. ,vol. 61, pp. 3084- 3091 ,(2001)
Allison L. Bayer, Aixin Yu, Thomas R. Malek, Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells. Journal of Immunology. ,vol. 178, pp. 4062- 4071 ,(2007) , 10.4049/JIMMUNOL.178.7.4062
Matthew A. Burchill, Christine A. Goetz, Martin Prlic, Jennifer J. O’Neil, Ian R. Harmon, Steven J. Bensinger, Laurence A. Turka, Paul Brennan, Stephen C. Jameson, Michael A. Farrar, Distinct Effects of STAT5 Activation on CD4+ and CD8+ T Cell Homeostasis: Development of CD4+CD25+ Regulatory T Cells versus CD8+ Memory T Cells Journal of Immunology. ,vol. 171, pp. 5853- 5864 ,(2003) , 10.4049/JIMMUNOL.171.11.5853
Shimon Sakaguchi, Noriko Sakaguchi, Misako Itoh, Masanao Asano, Masaaki Toda, Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. Journal of Immunology. ,vol. 155, pp. 1151- 1164 ,(1995)
Heinz Wiendl, Meike Mitsdoerffer, Valeska Hofmeister, Jörg Wischhusen, Antje Bornemann, Richard Meyermann, Elisabeth H. Weiss, Arthur Melms, Michael Weller, A functional role of HLA-G expression in human gliomas: an alternative strategy of immune escape. Journal of Immunology. ,vol. 168, pp. 4772- 4780 ,(2002) , 10.4049/JIMMUNOL.168.9.4772
Yoshiteru Nakano, Etsushi Kuroda, Tomohiro Kito, Akira Yokota, Uki Yamashita, Induction of macrophagic prostaglandin E2 synthesis by glioma cells. Journal of Neurosurgery. ,vol. 104, pp. 574- 582 ,(2006) , 10.3171/JNS.2006.104.4.574