作者: Cleo E. Rolle , Sadhak Sengupta , Maciej S. Lesniak
DOI: 10.1007/978-1-4614-3146-6_5
关键词: Interleukin 10 、 Cancer research 、 Tumor Escape 、 Biology 、 Immunity 、 Glioma 、 Microglia 、 Immune system 、 Immune tolerance 、 Antigen-presenting cell
摘要: A major contributing factor to glioma development and progression is its ability evade the immune system. This chapter will explore mechanisms utilized by mediate immunosuppression evasion. These include intrinsic linked location within brain interactions between cells cells. Lack of recruitment naive effector perhaps accounts for most suppression mediated these tumor enhanced increased microglia which resemble immature antigen presenting that are unable support T-cell immunity. Furthermore, secreted factors like TGF-β, COX-2 IL-10, altered costimulatory molecules inhibition STAT-3 all contribute expansion regulatory T cells, further modulate immunosuppressive environment glioma. In light findings, multiple immunotherapeutic treatment modalities currently being explored.