Treatment of murine primary brain tumors with systemic interleukin-2 and tumor-infiltrating lymphocytes.
作者： Stephen C. Saris , Paul Spiess , Daniel M. Lieberman , Shan Lin , Stuart Walbridge
DOI: 10.3171/JNS.1992.76.3.0513
关键词:
摘要: ✓ Methods have recently been described for the isolation and expansion of lymphocytes that trafficked into animal human tumors. These CD8-positive tumor-infiltrating (TIL's) exceptional trafficking ability to, efficacy against, tumor targets in extracranial sites. Prior to Phase I clinical trials patients with gliomas, adoptive immunotherapy TIL's was studied a mouse model primary brain tumors determine if intracerebral similar response. Glioma 261 (GL261) were grown subcutaneous space C57BL/6 mice. After enzymatic digestion, cells incubated vitro interleukin-2 (IL-2) until confluent population T present. The these tested against fresh GL261 chromium release assay; vivo liver irradiated nonirradiated brain. Mice received one following: intraperitone...
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