Rat Brain Tumor Models and the Statistical Evaluation of Survival Data in Experimental Neuro-Oncology

摘要: With the growing interest in gene therapy of brain tumors, there is a major need for suitable animal models that can be used to assess efficacy various approaches genetically engineer tumor cells. This chapter will selective rather than comprehensive, and focus entirely on rat models, their utility evaluating treatment modalities, statistical evaluation survival data. Two recent reviews (1,2) provide much useful information about number discussed here, interested readers are referred these additional details relating tumors described by us. Murine (3,4),canine (5,6),and feline (2,7) have been described, but not discussed. The one most widely experimental animals (8,9) neuro-oncology since mid-1970s (10). Druckrey (11), Benda, Schmidek, Swenberg, Koestner (12–16) associates reported central nervous system could induced selectively reproducibly adult rats had given repeated, weekly, intravenous (iv) injections N-methylnitrosourea (NMU). Contemporaneous with this, (11) Swenberg (16) also progeny pregnant single iv injection N-ethyl-N-nitrosourea (ENU). These studies led development were easily reproduced, did require topical application chemical carcinogen brain. At same time, Bigner et al. (6) an avian sarcoma virus-induced model, which has proven useful. Some general principles use presented, brief descriptions reviewed, respective advantages limitations Xenograft (17), based intracerebral transplantation human into immunologically deficient nude rats,