Low grade glioma: a measuring radiographic response to radiotherapy.

摘要: Purpose: We set out to determine the rate of response low-grade (WHO Grade II) gliomas radiotherapy and analyze relationship between radiographic response, symptom control patient survival. Methods: Patients were eligible for this study if they had received pathologically confirmed, residual, supratentorial astrocytoma, oligodendroglioma, or mixed glioma, imaging studies (baseline follow-up) available review . Percent change in tumor size timing determined by maximum linear measurement, area volume measurement using an ellipsoid model, vol- ume image segmentation. For each method, was defined firstly as a ‡ 50% decrease (partial response), secondly equivalent (normalized partial response). Relationships clinical improvement progression-free survival analyzed Cox Proportional Hazard's model. Results: Twenty-one patients database (13 male, 8 female; ages 22-66 years) met eligibility criteria. T wenty imaged com- puted tomography, 18 astrocytoma 15 irradiated soon after sur gery. Responses common not felt be due steroid effect. Use normalized criteria improved agreement assessment 4 methods. Median time 2.8 months (range, 1.5-11). Sixteen (76%) neurologi- cally, median progression 4.8 years 5-year 43%. W e did detect statistically significant association (as measured any method), symptomatology Conclusions: Low-grade are moderately radioresponsive. may over-estimate number responses unless reduction is used define response. The best way measure remains uncer - tain because neither visual, area, nor changes confidently predicted outcomes.