Impact of Genotype and Morphology on the Prognosis of Glioblastoma

摘要: The recognition of molecular subsets among glioblastomas has raised the question whether distinct mutations in glioblastoma-associated genes may serve as prognostic markers. present study on (GBM) from 97 consecutively sampled adult patients is based a clinical, histopathological, immunohistochemical, and genetic analysis. Parameters assessed were age at diagnosis, survival, cell type, proliferation, necrosis, microvascular sarcomatous growth, lymphocytic infiltration, thromboses, calcifications, GFAP expression, MIB-1 index, loss heterozygosity (LOH) chromosomal arms 1p, 10p, 10q, 17p, 19q structural alterations TP53 , EGFR PTEN genes. As previous studies, younger was significantly associated with better survival. Among parameters, LOH10q emerged favorable poor factors, respectively. factor independent primary or secondary. LOH1p 19q, lesions suspected to be over-represented long term survivors malignant glioma, not However, combination LOH19q defined GBM Notably, these did exhibit morphological features reminiscent oligodendroglioma. These findings indicate that genotyping glioblastoma provide clinical information importance.