Patient age, histologic features, and length of survival in patients with glioblastoma multiforme

摘要: Histologic sections from 71 patients with glioblastoma multiforme were reviewed to identify histologic prognostic factors and explain the significantly shorter survival in older patients. Slides studied for 14 variables a group of 35 aged less 45 years 36 65 or more. The relation these length age was then investigated. results document marked cytologic heterogeneity reaffirm importance necrosis as factor. further suggest that whose glioblastomas contained microcysts, pseudopalisading, cells astrocytic differentiation, large areas better differentiated glioma, did than those lesions homogeneously composed small lesion had median nuclear size. study reaffirmed strong (P 0.0001) negative relationship between advancing duration postoperative survival. presence necrosis, smaller standard deviation size, extent vascular proliferation, absence well neoplastic fibrillary astrocytes, neoplasms related patient offered possible explanation at least part observed effect. However, remained significant when adjusted other variables, effect must rest largely on detected this morphologic study.