Subsets of Glioblastoma Multiforme Defined by Molecular Genetic Analysis

摘要: Glioblastoma multiforme is a clinically and histologically heterogeneous lesion; however, to date, it has not been possible subdivide glioblastomas on clinical, histopathological or biological basis. Previous studies have demonstrated that loss of portions chromosomes 10 17 amplification the epidermal growth factor receptor (EGFR) gene are most frequent genetic alterations in glioblastoma. We therefore examined 74 from 67 patients for heterozygosity 17, gene, determine whether can be subtyped Using Southern blot analysis we were able detect different patterns genomic alterations. Eighteen informative characterized by short arm chromosome tumor tissue. Forty-five 64 showed 10. Amplification was noted 25 restricted those had lost Epidermal occurred significantly more often without 17p than with (p = 0.01). In addition, younger EGFR 0.001). These data emphasize heterogeneity glioblastoma suggest division into subsets.