The Nf1–/+; Trp53–/+cis Mouse Model of Anaplastic Astrocytoma and Secondary Glioblastoma: Dissecting Genetic Susceptibility to Brain Cancer

摘要: Astrocytic gliomas are the most common primary brain tumors. They include diffuse astrocytomas, mixed oligoastrocytoma, anaplastic and a subset of glioblastoma multiforme (GBM). Studies on human GBM have shown that upregulation Ras signaling pathway disruption p53 checkpoint central to formation these Although much is now known about molecular pathways altered in tumors, they remain largely incurable, primarily due their infiltration lack response chemotherapeutics. The Nf1–/+; Trp53–/+cis mouse model develops astrocytoma with histology closely resembles tumors seen patients. incidence astrocytic varies depending inheritance mutations from mother or father genetic background. Males females show different effects, suggesting sex influences epigenetic factors determine susceptibility an individual animal gliomas. This system, including both genetically engineered mice derivative cell lines, useful for understanding basic biological mechanisms underlying preclinical testing experimental therapeutics.