Loss of heterozygosity for chromosomes 1 or 14 defines subsets of advanced neuroblastomas.

摘要: Neuroblastomas have been characterized genetically by N- myc amplification and deletions or loss of heterozygosity (LOH) for the short arm chromosome 1. However, recent studies suggested deletion allelic involving at least three other arms, 11q, 14q, 17p. Therefore, we undertook an analysis these respective chromosomal arms to determine frequency pattern LOH as well correlation findings with biological clinical variables. A group 24 pairs normal tumor DNAs was chosen that were representative patients different ages stages. substantial (≥20%) found only 1p whereas occurred in ≤5% cases. On basis results, extended a total 59 neuroblastomas, 15 cases (25%) 14q 10 43 informative (23%). (25%). This confirmed almost exclusively advanced stages disease. Furthermore, usually independent each other, frequently associated amplification, not. Thus, our results demonstrate neuroblastomas are complex there two distinct loci putative suppressor genes deleted independently this tumor, both which