Molecular analysis of chromosomh 1 abnormalities in human gliomas reveals frequent loss of 1p in oligodendroglial tumors
作者： M. Josefa Bello , Jesus Vaquero , Jose M. De Campos , M. Elena Kusak , Jose L. Sarasa
关键词: Oligodendroglioma 、 Oligodendroglial Tumor 、 Chromosome 、 Restriction fragment length polymorphism 、 Hybridization probe 、 Biology 、 Central nervous system disease 、 Gene 、 Pathology 、 genomic DNA
摘要: Alterations of the short arm chromosome I are recurrently found in cytogenetic analysis malignant gliomas, and deletions Ip36-p32 region characterize at least higher-grade tumors, glioblsstoma multiforme. Molecular tumor-derived normal genomic DNA from 57 cases using a panel I-specific probes showed LOH 16 tumors. Allelic losses on p were primarily restricted to glioblastoma multiforme (2/II) tumors with major oligodendroglial component: grade II oligodendrogliomas (6/6), III anaplastic (5/6) II-III mixed oligo-astrocytomas (2/3). Losses for Iq markers detected only tumor (glioblastoma multiforme). Our data suggest that anomalies Ip oligodendrogliomas, whereas they rare events astrocytic indicate tumor-suppressor gene p36-p32 is involved development brain differentiation. © 1994 Wiley-Liss, Inc.
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