Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis.
作者： Tetsuro Sano , Huai Lin , Xiashan Chen , Lauren A Langford , Dimpy Koul
DOI:
关键词: PTEN 、 Gene expression 、 Locus (genetics) 、 Gene 、 Gene product 、 Cell growth 、 Tumor suppressor gene 、 Somatic cell 、 Biology 、 Cancer research
摘要: MMAC/PTEN, a tumor suppressor gene located on chromosome 10q, has recently been shown to act as phosphatidylinositol 3,4,5-triphosphate phosphatase and modulate cell growth apoptosis. Somatic mutations of MMAC/PTEN have reported in number human cancers, especially glioblastoma multiforme (GBM), although the identified (∼10–35%) is significantly lower than frequency LOH affecting locus specimens (∼75–95%). To further investigate possible alterations that may affect we examined expression by reverse transcription-PCR series gliomas. A significant difference (P
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