Genetic and signaling pathway alterations in glioblastoma relevance to novel targeted therapies

摘要: Glioblastomas multiforme (GBM) is the most common malignant primary brain tumor in adults. GBM patients have a dismal prognosis, with median survival of less than 1 year. During past decade, significant advances been made our understanding molecular pathogenesis these tumors. Specific genetic defects identified that appear to be important for development, as well maintenance characteristics are associated GBM. Some aberrations prognostic significance. However, even more exciting this era molecularly targeted therapy clues gene alterations provide identifying signaling mechanisms responsible carcinogenesis, and potential therapeutic targets. Cancer drug currently undergoing major transition an attempt move from use cytotoxic drugs towards mechanism-based drugs. Advances such decoding human genome, combinatorial chemistry, expression profiling led increase rate at which new being developed. In review, we will describe pathway relevance development treatment