An antisense EGFR oligodeoxynucleotide enveloped in LipofectinR induces growth inhibition in human malignant gliomas in vitro
作者： Noriaki Sugawa , Satoshi Ueda , Yoshio Nakagawa , Hoyoku Nishino , Kazuto Nosaka
关键词: Tyrosine kinase 、 Sense (molecular biology) 、 Cancer research 、 Growth factor receptor 、 Growth factor 、 Epidermal growth factor 、 Genetic enhancement 、 Epidermal growth factor receptor 、 Biology 、 Growth inhibition
摘要: Epidermal growth factor receptor (EGFR) plays an important role in the progression of malignancy gliomas. We studied inhibition malignant glioma cell lines using antisense EGFR oligodeoxynucleotide enveloped with LipofectinR. At a concentration 5 μM LipofectinR, proliferation three was significantly inhibited (p < 0.05) compared that cells exposed to sense oligodeoxynucleotide. The activity tyrosine kinase and DNA synthesis also suppressed 0.05). These findings show LipofectinR has possibility become useful gene therapy against
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